Albert Wesker of Resident Evil seeks to capture all the DNA of the words most icon killers. Tamara, Dr. Herbert West, Dr. Seth Brudle, Dr. Harleen Quinzel, and Michael Myers assist Wesker in recovering the DNA. Dr. Harleen Quinzel enters the mind of Hannibal Lecter to learn how to open the puzzle box. Freddy Krueger returns from another dimension and inhabits Dr. Harleen Quinzel's body to destroy the Hive from within and lure Albert Wesker into turning over the puzzle box in order to seek revenge on Pinhead. The Punisher and Rachel Cole-Alves plot to kill Wesker and infiltrate the Hive, but first they must defeat Darkman and a hoard of zombies.

Director Russell, head of a secret government agency, is in search of the Necronomicon and makes a deal with Freddy Krueger to find the book and release its powers by spilling the blood of Ash Williams. Freddy recruits Michael Myers and Jason Voorhees as they battle Ghostface and Leatherface on their way to finding Ash Williams. AKA. Freddy vs Jason vs Myers vs Leatherface vs Ghostface vs Ash Williams.